Personal practice Management of constitutional delay of growth and puberty
نویسنده
چکیده
Constitutional delay of growth and puberty (CDGP) is not a disease but a common condition in which puberty and its associated growth spurt occur at an age which is near the extreme of the normal range. Growth at puberty is intimately related to the stage of pubertal development and this is why, quite appropriately, both growth and puberty are implicit in the name, although it could be argued that they occur in an incorrect order. It is an important condition to recognise as many such children only need reassurance although some will require, if only for psychological reasons, therapeutic intervention to improve their short term growth. There is much information available about the anthropometric progress of children with constitutional delay of growth and puberty and we have attempted to correlate this with our more recent understanding of possible options for the manipulation of the endocrinology of puberty.
منابع مشابه
Treatment of constitutional delay of growth and puberty with oxandrolone compared with growth hormone.
The effects of oxandrolone or biosynthetic human growth hormone (r-hGH) on the growth of 26 boys with constitutional delay of growth and puberty were studied. Both regimens increased growth rate twofold, oxandrolone to a greater extent than r-hGH. We conclude that oxandrolone is a more effective method of increasing growth rate in such children.
متن کاملOral treatment for constitutional delay of growth and puberty in boys: a randomised trial of an anabolic steroid or testosterone undecanoate.
Thirty three boys (mean 14.6 years old, range 12.8-16.2 years) with constitutional delay of growth and puberty were randomised into two groups to determine which form of oral treatment would give the better anthropometric response. The two drugs were administered by mouth (one tablet/day) for a mean of 3.5 months (range 3-7 months). At randomisation, 17 boys received testosterone undecanoate (4...
متن کاملDouble blind placebo controlled trial of low dose oxandrolone in the treatment of boys with constitutional delay of growth and puberty.
Nineteen boys, mean age 14.4 years (range 12.9-16.3), with constitutional delay of growth and puberty were randomised into two groups in a double blind fashion for a three month period. Ten boys received oxandrolone, 2.5 mg per day (mean dose 0.072 mg/kg/day), and nine boys were treated with placebo. Mean growth velocity increased from 4.5 cm/year in the oxandrolone treated group to 9.6 cm/year...
متن کاملDiagnostic Accuracy of Growth Rate in Differentiating Etiologies of Short Stature in Children
Background Short stature is a manifestation of a wide variety of conditions that some of which may be amenable to timely treatment and a suboptimal growth rate may be an early marker pointing to the cause of growth retardation. This study was conducted to evaluate the diagnostic utility of growth rate in differential diagnosis of children with short stature. Materials and Methods All children ...
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